The Synergistic Combination of PEA & Luteolin
When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant, and neuroprotective properties. Coadministration of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone. This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.* (Impellizzeri 2018)